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Twitch the Heprat

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Hepatitis (plural: hepatitides) is a medical condition defined by the inflammation of the liver and characterized by the presence of inflammatory cells in the tissue of the organ. The name is from the Greek hêpar (ἧπαρ), the stem of which is hēpat- (ἡπατ-), meaning of the liver, and suffix -itis, meaning \"inflammation\" (c. 1727).[1] The condition can be self-limiting (healing on its own) or can progress to fibrosis (scarring) and cirrhosis.

Hepatitis may occur with limited or no symptoms, but often leads to jaundice, poor appetite and malaise. Hepatitis is acute when it lasts less than six months and chronic when it persists longer. Worldwide, hepatitis viruses are the most common cause of the condition, but hepatitis can be caused by other infections, toxic substances (notably alcohol, certain medications, some industrial organic solvents and plants), and autoimmune diseases.

Initial features are of nonspecific flu-like symptoms, common to almost all acute viral infections and may include malaise, muscle and joint aches, fever, nausea or vomiting, diarrhea, and headache. More specific symptoms, which can be present in acute hepatitis from any cause, are: profound loss of appetite, aversion to smoking among smokers, dark urine, yellowing of the eyes and skin and abdominal discomfort. Physical findings are usually minimal, apart from jaundice, tender enlargement of the liver, enlarged lymph nodes in 5%, and enlargement of the spleen. Acute viral hepatitis is more likely to be asymptomatic in children. Symptomatic individuals may present after a convalescent stage of 7 to 10 days, with the total illness lasting weeks.[2] A small proportion of people with acute hepatitis progress to acute liver failure, in which the liver is unable to remove harmful substances from the blood (leading to confusion and coma due to hepatic encephalopathy) and produce blood proteins (leading to peripheral edema and bleeding).[2]

Chronic hepatitis may cause nonspecific symptoms such as malaise, tiredness and weakness, and often leads to no symptoms at all. It is commonly identified on blood tests performed either for screening or to evaluate nonspecific symptoms. The presence of jaundice indicates advanced liver damage. On physical examination there may be enlargement of the liver.[3] Extensive damage to and scarring of liver (i.e. cirrhosis) leads to weight loss, easy bruising and bleeding, peripheral edema (swelling of the legs) and accumulation of ascites (fluid in the abdomen). Eventually, cirrhosis may lead to various complications: esophageal varices (enlarged veins in the wall of the esophagus that can cause life-threatening bleeding), hepatic encephalopathy (confusion and coma) and hepatorenal syndrome (kidney dysfunction). Acne, abnormal menstruation, lung scarring, inflammation of the thyroid gland and kidneys may be present in women with autoimmune hepatitis.[3]

The outcome of hepatitis depends heavily on the disease or condition that is causing the symptoms. For some causes, such as subclinical Hepatitis A infection, the person may not experience any symptoms and will recover without any long term effects. For other causes hepatitis can result in irreparable damage to the liver and require a liver transplant.[2] A subset referred to in a 1993 classification as \"hyperacute\" liver failure can happen in less than a week.[55] The liver can regenerate damaged cells.[56] Chronic damage to the liver can result in the formation of scar tissue called fibrosis and can result in nodules that block the liver from functioning properly; this condition is called cirrhosis and is not reversible.[57] Cirrhosis may indicate a liver transplant is necessary. Another complication of chronic hepatitis is liver cancer, specifically hepatocellular carcinoma.[58]

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